Biocompatible oligo-oxazoline crosslinkers: Towards advanced chitosans for controlled dug release

Chitosan, a natural and abundant biopolymer has been long explored as biocompatible material for the preparation of drug delivery devices. This strategy mostly accomplished using chemically crosslinked chitosan leading to more stable scaffolds. However, crosslinking shown reduce both biocompatibility swelling. In this work was with novel crosslinkers, based on oligo-oxazolines glycidyl methacrylate copolymers, patches very high swelling capacity. Dexamethasone therapeutics is strongly enhanced by controlled release administration. study shows that oligo-oxazoline-crosslinked suitable biomaterial loading dexamethasone.